Increasing potential of HER3 signaling in colon cancer progression and therapy.
نویسنده
چکیده
HER3 protein levels at the cancer cell plasma membrane are directly correlated with reduced survival in patients with colorectal cancer. In colorectal cancer cells, HER3 blockade restricted cellular growth (G(2)-M arrest), survival, migration, and invasion, and potentiated the chemotherapeutic effect of 5-FU, supporting strategies that target HER3 in subsets of patients with colorectal cancer.
منابع مشابه
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عنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 18 4 شماره
صفحات -
تاریخ انتشار 2012